Intelligent Systems

Clinical trial paradigms are changing

A couple of years ago Wyeth introduced a new R&D protocol in drug development. It was named “Learn & Confirm” and relies most heavily on biomarkers and pharmacogenomic approaches.

As part of Learn and Confirm, Wyeth drug-development teams were encouraged to examine each compound coming through the pipeline for ways that the company can employ a biomarker-based or pharmacogenomic approach that can help move it downstream.

This R&D Methodology was based on the research developed by Lewis B. Sheiner synthesized in the paper  “Clinical Pharmacology and Therapeutics”

This methodology is naturally consistent with the unicist complexity research methodology.  Therefore we working with CROs to expand this technology using the unicist healthcare cybernetic approach synthesized in the Unicist Cyberstation.

Diego Belohlavek

NOTE: We suggest you register in this “Conceptual Knowledge Reservoir” to receive updates on the new developments: 

The Intelligence Quotient only measures dualistic logic

Our work and research with gifted people, having an IQ above 130 drove to the conclusion that this gift allows adapting to aspects of reality that can be managed with dualistic logic. Gifted people are extremely successful when dealing with dualistic environments solving systemic problems.

But, on the other hand, they tend to generate fallacious behaviors when they are forced to enter into complex adaptive systems if they do not have the skills for developing action-reflection-action processes. In this context these processes allow apprehending the nature of complex systems in order to be able to manage them.

These individuals tend to use systemic palliatives to avoid dealing with complexity (such as: statistics, analogies, etc.). What allows them to deal with complexity is their level of ontointelligence, which includes their type of thought, their strategic intelligence and their ethical intelligence.

The problem with many high IQ individuals is that their gift is also their handicap. And this “handicap” hinders their reflection capacity unless they are able to use conceptual thinking and have a value adding ethical intelligence to approach reality.

The conclusion is that an extreme high IQ is not an advantage to deal with complex adaptive systems such as businesses. It is a gift to manage the systemic aspects of processes but it is a handicap to deal with the adaptive aspects.

Learn more: 

Dualistic logic is functional to deal with systemic problems but drives to “aprioristic” fallacies when dealing with complex problems. The IQ allows managing dualistic logic to deal with systemic problems and ontointelligence allows managing the double dialectical logic to solve complex problems.

Unicist Press Committee

NOTE: The Unicist Research Institute was the pioneer in complexity science research and became a private global decentralized world-class research organization in the field of human adaptive systems.

Healthcare: The ontogentic algorithm of evolution

Evolution implies the existence of a taxonomy to achieve a purpose. The first step appears to be putting the purpose into action. This implies a previous taxonomic step: the understanding of the purpose.

Then the first step is putting it into action. Without understanding no action is possible.

The second step is then finding a way to optimize the energy; thus the energy conservation principle is applied.

When this taxonomy is respected and successful, individual are evolving. This implies that they add value to the environment, obtain the counterpart and learn from the environment at the same time.

Evolution implies being aware of reality and making conscious actions in order to adapt to the environment.

Access more information in the book “The Ontogenesis of Evolution” at the Unicist Library:

Press Committee
The Unicist Research Institute

NOTE: The Unicist Research Institute was the pioneer in complexity science research and became a global decentralized world-class research organization in the field of human adaptive systems.

Installing an expansion-model in the Healthcare Industry

The expansion of businesses implies expanding their vital space. This requires having both a growth ethics and a growth ideology.

In order to grow, healthcare businesses need to have the capacity to expand the boundaries with a strong patient-orientation and need to be able to develop a competitive advantage that has to be perceived by the market.

Growth is based on an attitude, which is what appears on the surface of the integration of growth ethics and growth ideology.

Growth is an attitude that is perceived, in most of the cultures, as a taboo. Therefore, it needs to be justified with an additional value generation for the market and for the coming generations.

Installing an expansion-model requires a leader who represents this growth ethics and ideology and is able to transform them into operational procedures. This leader has to be strong because s/he has to overcome the opposition of the conservatives who will try to avoid the expansion of the business in order to sustain their comfort zone.

Business Architecture needs an integrative vision

The architecture of a business solution needs to be achieved with an integrative vision in which the individual sees the solution as a unified field, being capable of describing then the elements that integrate such solution.

This requires being able to face a reflection process. In the following lines you will have access to a research work carried out by a group of researches from Northwestern University, Drexel University, Philadelphia and Source Signal Imaging.

“People sometimes solve problems with a unique process called insight, accompanied by an “Aha!” experience. It has long been unclear whether different cognitive and neural processes lead to insight versus noninsight solutions, or if solutions differ only in subsequent subjective feeling. Recent behavioral studies indicate distinct patterns of performance and suggest differential hemispheric involvement for insight and noninsight solutions.”

Access the complete paper:

Unicist Tweetinar on ACOs and Patient Centered Management

Accountable Care Organizations are, among other aspects, a way to introduce Patient Centered Management in the healthcare business.

unicist patient centered organizationThe basics of medicine are patient centered. That is why the regulation of the activity focusing on patients is just a back to basics. Patient Centered Management is an object driven solution to structure patient orientation.

Electronic Patient Records are the paradigmatic sign of this approach. Electronic Healthcare records are their natural complement in order to include the aspects that deal with the diseases that are being considered.

Electronic Medical Records, being focused on medical activity, allow putting this patient orientation into action.

The EMR that are being fostered are the natural step to start with a structured patient orientation.

There will be a (one hour) Unicist Tweetinar on June 13 at 10:00 am (Eastern Time) on the ontology of Patient Centered Management and its integration in a system including EMR, EHR, EPR. It will be developed at

The Unicist Ontological Structure of Small Businesses

Five extremely successful growth programs with small businesses were the final test for the unicist ontology of small businesses.

Unicist Ontology of small BusinesessThe knowledge of their ontology allows small businesses to expand their activities without changing their nature. It also provides the limits of the expansion possibilities.

As it is self-evident the purpose of small businesses is profit. They are successful when their leaders are product/sales wizards meaning that they are able to influence their niche ensuring revenue.

At the same time they are investment reluctant. Any expenditure that has no necessary relationship with incomes is considered an investment and needs to be avoided. That is why they do not develop brands.

When they are involving they manage through cash-flow in order to ensure their survival. But successful small companies work with short term objectives and fully controlled operational action plans. The cash-flow is their final validation.

They use business objects basically to promote their products and services to generate revenue.

Organizations and their parts have a beginning and an end

The “Unicist Ontology of Organizational Equilibrium” describes the nature of organizational evolution. It is integrated by nine principles.

unicist-ontology-organizational-evolutionWe are presenting here one of the principles which is the one that rules the necessary action to develop maximal strategies to make business grow.

a) Every change of values implies the elimination of values, meaning that there is an end and a beginning.
b) Every organizational change implies a change of the values of the organization.
c) Organizations change from the outside to the inside and from top to bottom.
d) The results of changes need to be measured in the short and the long term.
e) The elapse of time makes the organizational structure of benefits obsolete.

Values are the materialization of ethics at an operational level. Organizations that seek for permanence need to die and rebirth with each change in order to adapt. No beginning nor change can exist if the ends are not accepted.

The apparent paradox is that the “end” is the energy conservation element. Beginning something new without finishing the preexisting organization is a utopia.

Learn more about the trend of ontology based solutions for businesses:

Healthcare businesses have to be adaptive as never before

Businesses are, by definition, adaptive systems that need to evolve in an adapted way in an environment. Therefore, knowledge is essential to manage businesses.

Ontology-of-the-knowledge-of-adaptive-systemsKnowledge implies having the necessary information to make decisions and implement them in order to generate a business.

Reliable knowledge can be achieved when the fundamental knowledge and the technical analytical knowledge have been acquired.

Fundamental analysis is the approach that defines the limits of the possibilities of the evolution of a given reality. Fundamentals define the boundaries implicit in the functionality of such reality.

Technical analysis deals with the cause-effect relation between “variables” that have been identified making a systemic compromise.

The discovery of the Unicist Ontology of Evolution and the structure of concepts that regulate the evolution of living beings and their deeds, established the structure for fundamental analysis integrating it with technical analysis in order to develop reliable knowledge to adapt in a smooth way to reality.

Learn more about the trend of ontology based solutions for businesses:

Simple thinking is the key for business growth

Simple thinking in decision making can be described as integrating the necessary mental amplitude and depth of thought in order to focus on solving a problem. Having sound knowledge of a reality is a precondition for simple thinking.

unicist-ontology-simple-thinkingSimple thinking implies focusing on a solution and not being concerned about a problem.

It requires having assumed the responsibility of solving a problem.

Easy thinking implies using pre-concepts to make decisions. In this case “the answers precede the questions”.

Complicated thinking happens when individuals cannot apprehend a reality because they do not have the necessary mental amplitude, depth of thought and focus.

In this case they make a complicated rational construction or an oversimplification to avoid responsibilities.

When facing uncertainty an individual cannot begin thinking in a simple way. Simple thinking will allow her/him to solve the problem after having learned about that reality. Simple thinking can only be developed by those who have conscious experiences in a field. Benchmarking is a simple thinking process or an easy fallacious solution.

Successful benchmarking requires having experienced the homologous and analogous activities that are being benchmarked.

Simple thinking is the key for business strategies. Maximal strategies, which happen beyond the limits of the actual business, require simple approaches.

Learn about the trend of ontology based solutions for businesses at: