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Unicist Functionalist Approach

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Unicist Functionalist Approach

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The next stage: Unicist Patient Centered Management

Patient Centered Management (PCM) is an organizational meta-model that allows empowering the work processes in healthcare institutions. It is homologous to Client Centered Management that is the natural model to guide work processes in businesses that was developed in the eighties.

Patient Centered ManagementOn the one hand, it works as a conceptual action guide to design work processes and, on the other hand, it is the main catalyst for continuous improvement, change management and innovation management.

PCM is driven by patient orientation. The purpose of the model is to assure results, and includes a quality assurance system that sustains the value added.

The information technology that sustains the PCM implies the integration of the three concepts that underlie healthcare IT:

  • EMR, to sustain physicians’ activities
  • EHR, to deal with the diseases
  • EPR, to provide a safety environment for patients

Based on the functional and legal context, this integration works in a different way in each culture.

The PCM provides a conceptual structure of rules that makes an optimal integration of these IT solutions possible and introduces the concept of adaptive interfaces in order to ensure adapting to the feedback.

Meta-models require being extremely focused in order to avoid being perceived as meaningless. By definition they need to be ambiguous because they need to allow adapting to the specific operation of different environments.

Meta-models describe the natural structure of an activity. Therefore, they are cross-cultural, needing to establish the operational rules respecting the characteristics of the environment. These meta-models make the saying “design globally, operate locally” become real.

The specific PCM is mainly focused on satisfying the needs of the patients within an environment where all participants win. The purpose of the model is to establish the unified field of the therapeutics process, taking advantage of all the technologies available and minimizing the participation of different “health” providers to solve the patients’ problems.

Unicist Press Committee

NOTE: The Unicist Research Institute was the pioneer in complexity science research and became a private global decentralized leading research organization in the field of human adaptive systems. http://www.unicist.org


Unicist Business Modeling to organize Patient Orientation

The Unicist Business Process Model uses the model defined with the Unicist Business Modeler and transforms it into strategic actions and organizational design.

Thus the business process becomes defined and it is possible to introduce business objects and systems to install the necessary efficiency and foster the efficacy of the members of an organization.

The purpose is to transform the Unicist Business Model into operational procedures.

The active function is given by the definition of an adequate strategy that covers both the maximal and minimum strategies.

The energy conservation function is defined by the organizational design.

The unicist technology for Business Modeling allows modeling business concepts and transforms them into operational procedures.

The Unicist Business Modeler uses the Unicist Ontological Algorithms that have been researched and developed, the Unicist Standard Language and the Facts of an activity to define the necessary processes and objects to develop a business.

Diana Belohlavek

NOTE: The Unicist Research Institute was the pioneer in using the unicist logical approach in complexity science research and became a private global decentralized leading research organization in the field of human adaptive systems. It has an academic arm and a business arm.
https://www.unicist.org/healthcare/wp-content/uploads/2015/08/turi.pdf


Clinical trial paradigms are changing

A couple of years ago Wyeth introduced a new R&D protocol in drug development. It was named “Learn & Confirm” and relies most heavily on biomarkers and pharmacogenomic approaches.

As part of Learn and Confirm, Wyeth drug-development teams were encouraged to examine each compound coming through the pipeline for ways that the company can employ a biomarker-based or pharmacogenomic approach that can help move it downstream.

This R&D Methodology was based on the research developed by Lewis B. Sheiner synthesized in the paper  “Clinical Pharmacology and Therapeutics”

This methodology is naturally consistent with the unicist complexity research methodology.  Therefore we working with CROs to expand this technology using the unicist healthcare cybernetic approach synthesized in the Unicist Cyberstation.

Diego Belohlavek

NOTE: We suggest you register in this “Conceptual Knowledge Reservoir” to receive updates on the new developments:
http://www.unicist.org/healthcare/wp-login.php?action=register 


Homology between Unicist Concepts and Stem Cells

The function of stem cells in the human body is homologous to the function of concepts in the field of human actions. While stem cells can give rise to specialized cells and thus organs, essential concepts allow building unicist objects.

Essential ConceptUnicist objects are adaptive systems that have a concept and generate added value within a quality assurance system to fulfill the purpose of the concept. Unicist objects are interdependent entities that integrate a complex adaptive system.

The knowledge of the essential concepts is basic to build unicist objects because these objects are the materialization of a concept.

Under certain conditions, organs can be transplanted and this is also the case of unicist objects that can be replicated as long as they belong to homologous and analogous entities.

Objects are inserted into processes to produce specific results. The same way stem cells have the potential capacity to give birth to human organs, concepts can give birth to objects to produce results.

The knowledge of the Unicist Theory allows using a double dialectical approach to reality to emulate the organization of nature using an object driven organization.

Nature is organized by objects which can be observed in the ecosystem. The human body is an example of the organization of nature, where organs are homologous to unicist objects. That is why the transplantation of organs became possible.

While the structure of the different organs of the body derives from the stem cells, the unicist objects derive from the essential function of an entity that is defined by its concept.

Properties of Stem Cells and Concepts

Stem Cells

Concepts

They are unspecialized They are universal
They are capable of self-renewal They are timeless
They can give rise to specialized cells They allow building operational functions

Thus, stem cells and concepts are homologous. While essential concepts allow the construction of objects to insert into human adaptive processes, stem cells allow the building of organs that work as unicist objects to sustain the functionality of a complex adaptive system such as the human body.

Peter Belohlavek

NOTE: The Unicist Research Institute was the pioneer in using the unicist logical approach in complexity science research and became a private global decentralized leading research organization in the field of human adaptive systems. It has an academic arm and a business arm.
http://www.unicist.org/repo/#Unicist


Presentation of The Unicist School in Healthcare

The Unicist School of Economics and Businesses has now more than 50,000 followers in 56 countries. http://www.unicist.org/the-unicist-school/

The Unicist School

Access The Unicist School

This school fosters the emulation of nature in the organization of social, institutional and individual processes, which, by definition, are complex adaptive systems, saving energy in such processes.

It is based on the Unicist Theory and its applications using a logical approach to deal with complex adaptive systems.

This approach allowed integrating complexity sciences with systemic sciences and microeconomics with macroeconomics as unified fields.

Unfortunately, there are many “nature hackers” who prefer taking shortcuts to cheat the nature of things instead of making things simple.

The approach allowed simplifying economics and businesses by emulating the organization of nature. It allows dealing with the nature of processes by using unicist objects and managing their concepts.

It made complex adaptive systems reasonable, understandable and predictable using the double dialectical logic to define their functionality. It allowed simplifying businesses by emulating the organization of nature.

Unicist Press Committee

NOTE: The Unicist Research Institute was the pioneer in using the unicist logical approach in complexity science research and became a private global decentralized leading research organization in the field of human adaptive systems. It has an academic arm and a business arm.
https://www.unicist.org/healthcare/wp-content/uploads/2015/05/turi.pdf


Evolution is Purpose Driven: The Discovery of the Ontogenetic Intelligence of Nature

Darwins finchesThis research began in 1976 with the hypothesis that in nature there are mutations that are random but others that are driven by a purpose.

If this hypothesis was confirmed and there were a purpose, Peter Belohlavek concluded that there would have to be an intelligence that defined such purpose.

For this reason, Belohlavek researched on the essential structure implicit in nature’s intelligence to be able to predict and exert influence on the evolution of complex adaptive systems when possible.

Charles Darwin demonstrated the adaptation process of species that, having the same structural constitution, developed adaptive changes to live in a certain environment.

The hypothesis of Belohlavek’s research was that these changes were driven by an intelligence that underlies nature.

The Unified field of the Ontogenetic Intelligence of NatureHe concluded that each living creature’s evolution is ruled by its ontogenetic intelligence, that defines it as unique both in its species and individuality and that the essential structure of this intelligence is integrated by a purpose, an active principle (entropic function) and an energy conservation principle.

The research was focused on the unified field of living beings.

The basic assumption that sustains this development is that the evolution of living beings, their behaviors, actions and deeds are driven by the same logical structural framework.

This implies that there is an intelligence that defines the structural behavior of any entity that integrates this framework that allows predicting the behavior of all the entities where this intelligence is known.

You can find the complete document on the “Discovery of the Ontogenetic Intelligence of Nature” at: http://www.unicist.org/repo/#Unicist

Unicist Press Committee

NOTE: The Unicist Research Institute was the pioneer in using the unicist logical approach in complexity science research and became a private global decentralized leading research organization in the field of human adaptive systems. It has an academic arm and a business arm.
http://www.unicist.org/repo/#Unicist


Unicist Research: Closing the gap between macro and micro behavior

The Unicist Research closed the gap between macro and micro behaviour. The unicist complexity research approach implies dealing with applications while researching, which requires that the lapse of research time be very long in order to achieve fully accurate predicted results before validating a hypothesis.

discoveries-unicist-2013-2014As it has been done every year since its foundation, The Unicist Research Institute synthesized this January the researches that had been finished until that time. After 38 years, 2013/2014, can be considered the year in which the integration of macro and micro behavior could be confirmed.

The gap between the macro and the micro cosmos has been and is still a problem that theoretical physicists are closing. The integration of the field of macro and micro behavior, that has been solved by Peter Belohlavek, is homologous. It allows integrating social behavior with individual behavior, making human complex adaptive systems manageable.

The publication of Conceptual Economics, Conceptual Anthropology and Conceptual Psychology are some of the milestones of this process that included the researches developed in 2013-2014 (see image above).

You can access Conceptual Economics and Conceptual Anthropology at:
http://www.unicist.org/repo/#Economy

If you want to access the “Drivers of Human Behavior” that explain the structure of human intelligence, please access: www.unicist.org/repo/#Psychology

Unicist Press Committee

NOTE: The Unicist Research Institute was the pioneer in using the unicist logical approach in complexity science research and became a private global decentralized leading research organization in the field of human adaptive systems. It has an academic arm and a business arm. http://www.unicist.org/repo/#Unicist


Proteins and Amino Acids: Discovery of the Unicist Ontology of Amino Acids

The Unicist Ontology of amino acids allows understanding its functionality and the possibilities of their integration to build proteins. Their purpose is given by the side chain which defines the different functions amino acids can fulfill.

Amino Acids

It has to be considered that the Unicist Ontology emulates the ontogenetic intelligence of nature that was discovered which defines that there is always a purpose, an active and entropic principle and an energy conservation principle. The unicist ontology of amino acids is a demonstration of how this intelligence works.

The active function of an amino acid is given by the carboxyl group that establishes a supplementary relationship with the R-group. The energy conservation function is given by the amino group, which establishes a complementary relationship with the R-group.

Amino acids are biologically organic compounds integrated by amine and carboxylic functional groups, driven by a side-chain specific to each amino acid. The key elements of an amino acid are carbon, hydrogen, oxygen, and nitrogen, though other elements are found in the side-chains of some amino acids.

Amino acids are the building blocks of peptides and proteins. They are composed of amine and carboxylic acid groups, separated by the alpha-carbon but the side chains on the alpha carbon vary with the acid. They are the subunits of proteins: amino acids make peptide chains, peptide chains make polypeptides, polypeptides make proteins.

Amino Acid StructureAmino acids are the structural units that build proteins. They join together to form short polymer chains called peptides or longer chains called either polypeptides or proteins. These polymers are linear and unbranched, with each amino acid within the chain attached to two neighboring amino acids.

Peptide Formation

Amides can be thought of as forming from the reaction of an amine and a carboxylic acid. In the same way, two amino acids can combine to form a dipeptide, held together by a peptide bond.

Peptides

A fourth amino acid would form a tetrapeptide, a fifth would form a pentapeptide, and so on. Short chains are referred to as peptides, chains of up to about 50 amino acids are polypeptides, and chains of more than 50 amino acids are proteins. Amino acids in peptide chains are called amino acid residues.

Classification of Amino Acids

Acidic amino acids and their amides: aspartic acid, asparagine, glutamic acid, glutamine.

Basic amino acids: histidine, lysine, arginine.

Aromatic amino acids: phenylalanine, tyrosine, tryptophan.

Sulfur containing amino acids: cysteine, methionine.

Imido acid: proline.

Hydrophobic side chains: glycine, alanine, valine, leucine, isoleucine.

Hydroxylic amino acids: serine, threonine, (tyrosine).

Learn more about amino acids at: http://www.biology.arizona.edu/biochemistry/problem_sets/aa/aa.html

Unicist Press Committee

NOTE: The Unicist Research Institute was the pioneer in using the unicist logical approach in complexity science research and became a private global decentralized leading research organization in the field of human adaptive systems. It has an academic arm and a business arm.
https://www.unicist.org/healthcare/wp-content/uploads/2015/02/turi.pdf


Abstract: Discovery of the Unicist Ontology of Health

The research on the unicist ontology of health, which began in 2001, was focused on finding the essential structure of health that allows understanding the multiple medical specialties and medical approaches that deal with “the art of healing”. This research was developed at The Unicist Research Institute and was led by Peter Belohlavek.

Paradoxically, it could be finished after the ontological structures of healthcare were discovered. This research integrated health and medical approaches in a “unified field”. The previous researches that sustained this discovery were:

Unicist Ontology of Health-The Unified Field of Healthcare
-Homology between Concepts and Stem Cells
-The Ontogenetic Intelligence of Nature
-The Fallacy of Organs and  Chronic Diseases
-The Unicist Structure of Viruses
-The Ontogenetic Map of Chronic Diseases
-The Ontogenetic Map of Addictions
-The Ontogenetic Map of Stress
-The Ontogenetic Map of Cures
-The Ontogenetic Map of Immune Systems
-The Ontogenetic Map of Therapeutics
-The Ontogenetic Map of Diseases

Health can be defined as the integration of organic functionality, psychic functionality and the functionality of the inner energy flow.

The organic functionality is defined by the functionality of organs which, working as complex adaptive systems, can only be measured based on the consequences of their function. Organic functionality also includes the functionality of inner systems, although they cannot be considered as organs (e.g: the immune system). The fallacy of organs functionality is a proof of the limits of the possibilities of organic functionality.
http://www.unicist.org/healthcare/unicist-ontology-of-health-the-fallacies-of-organs/

The psychic functionality is defined by the functionality of the instinctive, spiritual and psychological processes whether they are conscious or unconscious that allow individuals to adapt to the environment. The psychic functionality deals with the interpersonal and intrapersonal adaptive processes and with the meaning of life.

The energy-flow functionality can only be measured by the consequences of its lack of functionality. It implies that the human being considered as a system flows internally in a harmonic way. This allows individuals to live and adapt to the environment.

Fostering health requires ensuring that the psychic functionality, which is the active function of health, maintains and does not hinder the energy flow that sustains the functionality of organs. Fostering health requires stimulating a meaningful life where the interpersonal and intrapersonal adaptation conflicts can be managed.

Unicist Press Committee

NOTE: The Unicist Research Institute was the pioneer in using the unicist logical approach in complexity science research and became a private global decentralized leading research organization in the field of human adaptive systems. It has an academic arm and a business arm.
https://www.unicist.org/healthcare/wp-content/uploads/2015/01/turi.pdf


Adaptive clinical trials: An upgrade and energy saving methodology

The discovery of the unicist ontological structure of complex systems developed at The Unicist Research Institute provided the final input to develop a methodology for adaptive clinical trials. The unicist ontology of health that was discovered provided the basic background for this methodology: http://goo.gl/Ruwsr3

Clinical TrialsThis approach is based on the integration of aspects of traditional clinical trials, the concept of the “learn and confirm” standard and the unicist approach to complexity sciences.

This approach is based on the use of destructive tests, which are a special kind of falsification test (Karl Popper), to sustain the Phase I and Phase II clinical trials.

The objective of destructive tests is to confirm the limits of the functionality that is being tested.

They are necessary in the previous research work but their application in these phases allows providing a safe input to develop the following phases. Destructive tests are based on universal experimenting and on the knowledge of the conceptual foundations of what is being researched.

Clinical TrialsPhase III and IV are approaches that use non destructive tests that are analogous to the traditional clinical trials but with the inclusion of a quality assurance process that triggers a “learning” process when predefined limits are exceeded.

The “learn & confirm” methodology introduced at Wyeth changed the paradigms of clinical trials and introduced a conceptual simplification in the R&D processes that could not expand massively because of the non-evident economic benefits of this technology.

The unicist approach to adaptive clinical trials is an approach based on the complexity science research methodology developed at The Unicist Research Institute that simplified the discovery-learn-confirm method introduced by Wyeth and provides a secure approach to life-sciences.

A research consortium, coordinated by Peter Belohlavek, is being organized to develop this solution in real application fields. It is expected that this methodology becomes a standard within the next two years based on the shortening of the R&D processes and the saving of up to 50% of the costs.

Learn more about “What are complexity sciences” at:
http://www.unicist.org/repo/#Unicist

Unicist Press Committee

NOTE: The Unicist Research Institute was the pioneer in using the unicist logical approach in complexity science research and became a private global decentralized leading research organization in the field of human adaptive systems. It has an academic arm and a business arm.
https://www.unicist.org/healthcare/wp-content/uploads/2014/10/turi.pdf