B) Lifesciences


Transforming EMR into Adaptive Patient Centered Systems

Medical efficacy implies that physicians need to work within the complexity of human biology. They work in the field of adaptive systems. This implies that their efficacy curve has to be functional to deal with low programmed activities. Protocols sustain this essentially low programmed activity.

healthcare-cyberneticsParadoxically, there is a widespread perception that EMR/EHR has a low added value for medical practice. This perception hinders the upgrade of medical practice.

But:

1)  Is it that EMR and EHR have little added value or is it that they were designed as administrative systems?
2)  Is it possible to transform administrative EMR and EHR into adaptive systems with administrative information?
3)  How can the misuse of the transparency of the system be avoided?

These are some of the questions that can be solved using an object driven approach to healthcare.

The objects included in the EMR and EHR should emulate the problems physicians need to solve in their minds in medical practice. The basic objects are:

  • Diagnoses
  • Cures
  • Palliatives
  • Patients evolution
  • Prevention
  • Decision making
  • Knowledge bank

Objects driven EMR or EHR are such when they become a necessary part for physicians practice such as a golf stick is for the golfer or a racket is for a tennis player.

There have to be objects for exclusive private use with no access to anyone, such as the decision making alternatives a physician considers, and other objects that can be shared.

Administrative EMR or EHR can only be information reservoirs, legal defendants and control systems. The integration of object driven systems including adaptive objects with administrative functions is the conceptual answer to the problem. Basically, a new concept for interfaces is required.

Changing the interfaces is the first step to enter in the new stage where the computer is a natural part of the physician’s practice.

Diego Belohlavek

NOTE: The Unicist Research Institute was the pioneer in complexity science research and became a private global decentralized world-class research organization in the field of human adaptive systems. http://www.unicist.org


Clinical trial paradigms are changing

A couple of years ago Wyeth introduced a new R&D protocol in drug development. It was named “Learn & Confirm” and relies most heavily on biomarkers and pharmacogenomic approaches.

As part of Learn and Confirm, Wyeth drug-development teams were encouraged to examine each compound coming through the pipeline for ways that the company can employ a biomarker-based or pharmacogenomic approach that can help move it downstream.

This R&D Methodology was based on the research developed by Lewis B. Sheiner synthesized in the paper  “Clinical Pharmacology and Therapeutics”

This methodology is naturally consistent with the unicist complexity research methodology.  Therefore we working with CROs to expand this technology using the unicist healthcare cybernetic approach synthesized in the Unicist Cyberstation.

Diego Belohlavek

NOTE: We suggest you register in this “Conceptual Knowledge Reservoir” to receive updates on the new developments:
http://www.unicist.org/healthcare/wp-login.php?action=register 


Homology between Unicist Concepts and Stem Cells

The function of stem cells in the human body is homologous to the function of concepts in the field of human actions. While stem cells can give rise to specialized cells and thus organs, essential concepts allow building unicist objects.

Essential ConceptUnicist objects are adaptive systems that have a concept and generate added value within a quality assurance system to fulfill the purpose of the concept. Unicist objects are interdependent entities that integrate a complex adaptive system.

The knowledge of the essential concepts is basic to build unicist objects because these objects are the materialization of a concept.

Under certain conditions, organs can be transplanted and this is also the case of unicist objects that can be replicated as long as they belong to homologous and analogous entities.

Objects are inserted into processes to produce specific results. The same way stem cells have the potential capacity to give birth to human organs, concepts can give birth to objects to produce results.

The knowledge of the Unicist Theory allows using a double dialectical approach to reality to emulate the organization of nature using an object driven organization.

Nature is organized by objects which can be observed in the ecosystem. The human body is an example of the organization of nature, where organs are homologous to unicist objects. That is why the transplantation of organs became possible.

While the structure of the different organs of the body derives from the stem cells, the unicist objects derive from the essential function of an entity that is defined by its concept.

Properties of Stem Cells and Concepts

Stem Cells

Concepts

They are unspecialized They are universal
They are capable of self-renewal They are timeless
They can give rise to specialized cells They allow building operational functions

Thus, stem cells and concepts are homologous. While essential concepts allow the construction of objects to insert into human adaptive processes, stem cells allow the building of organs that work as unicist objects to sustain the functionality of a complex adaptive system such as the human body.

Peter Belohlavek

NOTE: The Unicist Research Institute was the pioneer in using the unicist logical approach in complexity science research and became a private global decentralized leading research organization in the field of human adaptive systems. It has an academic arm and a business arm.
http://www.unicist.org/repo/#Unicist


Abstract: Discovery of the Unicist Ontology of Health

The research on the unicist ontology of health, which began in 2001, was focused on finding the essential structure of health that allows understanding the multiple medical specialties and medical approaches that deal with “the art of healing”. This research was developed at The Unicist Research Institute and was led by Peter Belohlavek.

Paradoxically, it could be finished after the ontological structures of healthcare were discovered. This research integrated health and medical approaches in a “unified field”. The previous researches that sustained this discovery were:

Unicist Ontology of Health-The Unified Field of Healthcare
-Homology between Concepts and Stem Cells
-The Ontogenetic Intelligence of Nature
-The Fallacy of Organs and  Chronic Diseases
-The Unicist Structure of Viruses
-The Ontogenetic Map of Chronic Diseases
-The Ontogenetic Map of Addictions
-The Ontogenetic Map of Stress
-The Ontogenetic Map of Cures
-The Ontogenetic Map of Immune Systems
-The Ontogenetic Map of Therapeutics
-The Ontogenetic Map of Diseases

Health can be defined as the integration of organic functionality, psychic functionality and the functionality of the inner energy flow.

The organic functionality is defined by the functionality of organs which, working as complex adaptive systems, can only be measured based on the consequences of their function. Organic functionality also includes the functionality of inner systems, although they cannot be considered as organs (e.g: the immune system). The fallacy of organs functionality is a proof of the limits of the possibilities of organic functionality.
http://www.unicist.org/healthcare/unicist-ontology-of-health-the-fallacies-of-organs/

The psychic functionality is defined by the functionality of the instinctive, spiritual and psychological processes whether they are conscious or unconscious that allow individuals to adapt to the environment. The psychic functionality deals with the interpersonal and intrapersonal adaptive processes and with the meaning of life.

The energy-flow functionality can only be measured by the consequences of its lack of functionality. It implies that the human being considered as a system flows internally in a harmonic way. This allows individuals to live and adapt to the environment.

Fostering health requires ensuring that the psychic functionality, which is the active function of health, maintains and does not hinder the energy flow that sustains the functionality of organs. Fostering health requires stimulating a meaningful life where the interpersonal and intrapersonal adaptation conflicts can be managed.

Unicist Press Committee

NOTE: The Unicist Research Institute was the pioneer in using the unicist logical approach in complexity science research and became a private global decentralized leading research organization in the field of human adaptive systems. It has an academic arm and a business arm.
https://www.unicist.org/healthcare/wp-content/uploads/2015/01/turi.pdf


Unicist Ontology of Health: The Fallacies of Organs

The unicist ontology of fallacies and a particular case of the fallacies of organs will be introduced following a synthetic description on the fallacious behavior of the kidneys and its consequences in the human body.The case of the fallacious behavior of kidneys will be presented as an example for its consequences in the human body.

The fallacies of organs are either movement or inaction fallacies. They are natural responses when the survival of the object-organ is being threatened by the “system” that pretend to ensure the survival of the organ in spite of the consequences on the whole body.

The synthetic description of the case of kidney fallacies will provide the understanding of how the fallacious behavior occurs.

Fallacy of Kidney’s Behavior

The kidney generates fallacious responses when it is threatened by dysfunctional blood flow. The kidney decides to survive itself in spite of the consequences on the organism.

Pre renal kidney failure is caused by conditions or substances that interfere with blood flow to the kidneys. Conditions that may leave the kidneys with insufficient blood flow or blood supply include:

Low blood pressure: Low blood pressure can be caused by severe bleeding, infection, dehydration, or shock.

Reduced blood flow: Reduced blood flow to the kidney can be caused by a weak heart, heart attack, or congestive heart failure.

Low blood volume: Low blood volume can be caused by severe dehydration and an excessive loss of fluid, which decreases the volume of blood and the amount of blood available to the kidneys.

High blood pressure makes the heart work harder and, over time, can damage blood vessels throughout the body. If the blood vessels in the kidneys are damaged, they may stop removing wastes and extra fluid from the body. The extra fluid in the blood vessels may then raise blood pressure even more. It’s a dangerous cycle.

High blood pressure is one of the leading causes of kidney failure, also called end-stage renal disease (ESRD). People with kidney failure must either receive a kidney transplant or have regular blood-cleansing treatments called dialysis. Every year, high blood pressure causes more than 25,000 new cases of kidney failure in the United States.

The fallacies of the kidney drive to chronic diseases or to destroying the organism and dying with it.

Conclusion

One of the consequences of systematic fallacious behavior is the generation of chronic dysfunctions of the organ. If the problem of blood pressure is not equilibrated, the kidney will tend to change its functionality which will hinder the fulfillment of its purpose.

Peter Belohlavek

NOTE: The Unicist Research Institute was the pioneer in using the unicist logical approach in complexity science research and became a private global decentralized leading research organization in the field of human adaptive systems. It has an academic arm and a business arm.
https://www.unicist.org/healthcare/wp-content/uploads/2014/06/turi.pdf


Unicist Logical Approach: Diagnoses managed as medical objects

Medical objects are encapsulated adaptive processes that have the necessary quality assurance to generate a predefined result.

Diagnostics Quality AssuranceMedical diagnoses happen within the scope of medicine but are regulated by the functional rules of universal diagnostics and are driven by the semiotic signs the diagnostician identifies.

Diagnoses can be considered from two different points of view. Seen from the diagnostician’s standpoint, they are a process that needs to be done to identify the problem that needs to be cured. But seen from the point of view of the therapeutic process, they are a medical object that defines the objective of the therapeutic process.

As a medical object, they need to have the necessary quality assurance to be fully reliable. To achieve this reliability they need to be based on reliable knowledge and develop the necessary destructive and non-destructive tests to confirm their validity.

As an object, they work as an adaptive system that modifies the diagnosis based on the feedback from the environment until the therapeutic process has shown its accuracy. The destructive tests are necessary to evaluate the limits of validity of the diagnoses while the non-destructive tests are done to confirm their functional validity.

To manage diagnoses as medical objects it is necessary that the EHR includes the possibility of managing them as adaptive systems.

Diego Belohlavek

NOTE: The Unicist Research Institute was the pioneer in complexity science research and became a private global decentralized leading research organization in the field of human adaptive systems. http://www.unicist.org


Beyond Medicine: the Fallacy of Organs and Chronic Diseases

The homology between the fallacies of organs and the human “mental” fallacies is presented based on the research on the unicist ontology of fallacies and their functionality.

Fallacies of OrgansThe human body can be considered as a paradigmatic complex system that needs to be approached as such in order to influence it. As nature is organized by interdependent objects it can be also considered that the human body is integrated by objects and processes that allow humans to be alive.

This work provides the fundamentals to understand the essential structure that underlies fallacies and their functionality whatever their origin.

The unicist ontology of fallacies and a particular case of the fallacies of organs will be introduced following a synthetic description on the fallacious behavior of the kidneys and its consequences in the human body.

It can be defined that the human body is composed by object-organs that are integrated in processes, are interdependent with other objects and have a semiautonomous integrated behavior.

Access the complete information at:
https://www.unicist.org/healthcare/wp-content/uploads/2013/03/fallacy-of-organs.pdf

Unicist Press Committee

NOTE: The Unicist Research Institute was the pioneer in complexity science research and became a private global decentralized world-class research organization in the field of human adaptive systems. http://www.unicist.org


What is Unicist Decision Making?

Unicist decision making is a conscious process of an individual or group where the justifications and foundations of possible action alternatives are evaluated to make a decision. It is focused on ensuring that the objectives are possible and not only probable.

The unicist double dialectical approach allows integrating the justifications of the purpose that needs to be achieved, with the justifications of the necessary actions, integrating them with their foundations to ensure the accuracy of the decision.

The dualistic approach hinders the integration of justifications and foundations, dividing the process into an independent analysis of the “what for” of the actions to be decided and the “why” the actions will produce the expected results.

The dualistic decision making process drives decisions into a voluntaristic, rationalistic or subjective context. This tends to produce paradoxical results and the need to have scapegoats for their consequences.

Learn more:
https://www.unicist.org/healthcare/wp-content/uploads/2013/01/decision_making_ontology_en.pdf 

Unicist Press Committee

NOTE: The Unicist Research Institute was the pioneer in complexity science research and became a global decentralized world-class research organization in the field of human adaptive systems. http://www.unicist.org


Healthcare: The ontogentic algorithm of evolution

Evolution implies the existence of a taxonomy to achieve a purpose. The first step appears to be putting the purpose into action. This implies a previous taxonomic step: the understanding of the purpose.

Then the first step is putting it into action. Without understanding no action is possible.

The second step is then finding a way to optimize the energy; thus the energy conservation principle is applied.

When this taxonomy is respected and successful, individual are evolving. This implies that they add value to the environment, obtain the counterpart and learn from the environment at the same time.

Evolution implies being aware of reality and making conscious actions in order to adapt to the environment.

Access more information in the book “The Ontogenesis of Evolution” at the Unicist Library: www.unicist.com/books-pages/en/unicist_ontology_evolution_en3s.php

Press Committee
The Unicist Research Institute

NOTE: The Unicist Research Institute was the pioneer in complexity science research and became a global decentralized world-class research organization in the field of human adaptive systems. https://www.unicist.org/healthcare/wp-content/uploads/2012/07/turi.pdf


Unicist Ethics, the driver of accurate healthcare diagnoses

Until the Unicist Approach was applied to healthcare, medical failures were considered mistakes or malapraxis.

The Unicist Approach allowed defining the necessary context and the personal attitudes that are necessary to avoid paradoxical diagnosis and maximize the accuracy of the real diagnoses.

“A paradox exists when something is self-contradictory or absurd but in reality expresses a possible truth.

Health, educational and research diagnostics are a fertile ground for planting paradoxes.

The first part of the research on paradoxical functioning explains how paradoxes behave in the field of work, human action and in the healing art.

Appearance sustains paradoxes and also leads to fallacious perceptions. Finally, it can be said that paradoxes are sustained by fallacies.

This research results are presented in a synthetic but abstract language. To explain the concept of paradoxical behavior, synthetic language is required.

Paradoxes corrode human activity. Individuals are unaware of their paradoxical behavior. Unless working with a permanent and actual feedback with reality, paradoxes are usually discovered when it is too late.

In the art of healing the antidotes for paradoxical behaviors are always the same:

  • Real interest in the patient
  • Secure knowledge
  • Hard work
  • Control – quality assurance”

Access it at:
http://www.unicist.com/books-pages/en/ontological_diagnostics_en16.php
First you need to register: http://www.unicist.com

NOTE: The Unicist Research Institute was the pioneer in complexity science research and became a global decentralized world-class research organization in the field of human adaptive systems. https://www.unicist.org/healthcare/wp-content/uploads/2012/04/turi.pdf